I am broadly interested in the mechanisms of molecular evolution and in how they can be better inferred from large, densely-sampled phylogenomic and population-genomic datasets.


My current work is focused on modeling and inference of complex patterns of protein evolution and co-evolution from large comparative genomic data sets using novel data augmentation strategies and Markov-Chain Monte Carlo (MCMC).  I have also worked on improving likelihood-based approaches for detecting episodic molecular adaptation, sequence convergence, and on asymptotic methods for objective experimental design.  My doctoral work was largely focused on making better functional inferences along short evolutionary lineages (details forthcoming).


Doctoral dissertation: “Experimental Design and the Detection of Adaptive Molecular Divergence in Phylogenetics and Genomics.” (2007)  Thesis advisor: Caro-Beth Stewart

Research Interests


Adaptive molecular evolution

Phylogenomics and population genomics

Computational and Bayesian statistics


Phylogenetic theory

Human and primate evolution

Protein folding and evolvability

Objective experimental design


Software Downloads


codeML-ancestral: Calculate posterior expected convergent substitutions while integrating over uncertainty in ancestral states (Castoe, de Koning et al. 2009)


PLEX: Rapid analysis of large phylogenomic datasets using complex models (MCMC package with Wanjun Gu and David Pollock)


PIDAMEbL: Phylogenetic information and detection of adaptive molecular evolution by likelihood (de Koning, 2007; with Caro-Beth Stewart)


FENS: Facilitated estimates of nucleotide substitutions (pairwise methods for computing dN/dS; de Koning and Stewart; out of date)

 

News Feed

A. P. Jason de Koning, Ph.D.

    Postdoctoral Fellow

    Department of Biochemistry and Molecular Genetics

    David Pollock lab

    University of Colorado Denver

    School of Medicine

    Aurora CO  USA

New: The ‘partial sampling of substitution histories’

paper (de Koning, Gu, and Pollock, 2009) is out in February’s MBE.


Course materials for the “Introduction to Computational Genomics”

laboratory course can be found here.

http://mbe.oxfordjournals.org/cgi/content/abstract/msp228
http://jasondk.org/Teaching.html